410528-02-8 Palovarotene; Sohonos

Pwopriyete

Aparans blan nan koupe-blan solid
Pwen k ap fonn: 249-252 degre
Pwen bouyi: 592.3 ± 5 0. 0 degre
Dansite 1.11
Depo tanperati. Frijidè
Solubility DMSO (yon ti kras), asetat etil (yon ti kras, chofe), methanol (yon ti kras, chofe)
PKA4.26 ± 0. 10
 

Aplikasyon:

Palovarotene se yon agonist reseptè asid retinoik oralman ki disponib ak selectivite espesifik nan direksyon pou subtip gama nan RAR. Palovarotene diminye ALK2/SMAD depandan Cartilage fòmasyon ak diferansyasyon selil zo pa obligatwa RAR ak inhibition SMAD1/5/8 fosforilasyon, kidonk diminye en wout siyal nan BMP/ALK2 ak reyisi yon rediksyon nan andokondral zo.

 

Sinonim:

Palovarotèn

410528-02-8

Sohonos

Rg -667

Ro -3300074

CLM -001

palovaroteno

R-667

IPN -60120

RO3300074

R 667

4- ((1e) -2- (5,5,8, 8- hyl) -5, 6,7, 8- tetrahydronaphthalen -2- yl) ethenyl) benzoic asid

4- [(e) -2- [5,5,8, 8- Tetramethyl -3- (Pyrazol -1- YLM etil) -6, 7- dihydronaphthalen -2- yl] ethenyl] benzoic asid

Asid benzoik, 4- ((1e) -2- (5,6,7, 8- Tetrahydro -5, 5,8, 8- Tetrameth yl -3- (1h-pirazol -1- ylmethyl) -2- naphthalenyl) ethenyl)-

palovarotenom

4- {(1e) -2- [5,5,8, 8- hyl) -5, 6,7, 8- tetrahydronaphthalen -2- yl] ethenyl} benzoic asid

Asid benzoik, 4- [(1e) -2- [5,6,7, 8- tetrahydro -5, 5,8, 8- Tetrameth yl -3- (1h-pirazol -1- ylmethyl) -2- naphthalenyl] ethenyl]-

Sohonos

Palovarotene (R 667)

Gtpl8276

 

Baj popilè: 410528-02-8 Palovarotene; Sohonos, Lachin 410528-02-8 Palovarotene; Sohonos Konpayi fabrikasyon, Swèd