849217-68-1 cabozantinib

Pwopriyete

Aparans poud blan
Pwen k ap fonn: 212-215 degre
Pwen bouyi: 758.1 ± 6 0. 0 degre
Dansite 1.396
Depo tanperati. -20 degre
Solubility soluble nan DMSO
pka13. 86 ± 0. 70

 

Aplikasyon:

Cabozantinib (XL184) se yon milti-sib tirozin kinaz inhibiteur (TKI) ki ka anpeche ekspresyon an nan plizyè faktè kle tankou VEGFR1, VEGFR2, VEGFR3, Met, Axl, Twous, ki jwe wòl enpòtan nan siviv la, metastaz, ak angiojen nan selil yo.
Singularité a nan cabozantinib bay manti nan kapasite li nan pa sèlman anpeche VEGFR, men tou, espesyalman anpeche chemen an te rankontre. Chemen an Met pre relasyon ak pwopagasyon selil, diferansyasyon, rmaniman sitoskelèt, ak envazyon selil. Pa anpeche MET, cabozantinib ka gen efè ki ka geri ou sou dwòg ki reziste timè, ak efè inhibition li yo sou chemen an Met bay li yon "doub anti-kansè" kapasite.

Anplis de sa, cabozantinib ka anpeche jèn nan AXL, kidonk bloke anjyojenèz ak dirèkteman fè pwomosyon apoptoz selil timè. Mekanism yo inhibition miltip nan VEGFR, te rankontre, ak AXL pèmèt cabozantinib pwovoke rezistans timè pi dousman konpare ak tradisyonèl vaskilè andotelyo faktè kwasans reseptè inhibiteurs, kidonk demontre plis dirab efè ki ka geri nan tretman an.

 

Sinonim:

Cabozantinib

849217-68-1

XL184

Cometriq

Xl -184 baz gratis

N '-[4- [(6, 7- dimethoxy -4- quinolinyl) oxy] fenil] -n-(4- fluorophenyl) -1, 1-}}}}} {{

1- n-[4- (6, 7- dimethoxyquinolin -4- yl) oxyphenyl] {{6} } N '-(4- fluorophenyl) cyclopropane -1, 1- dicarboxamide

Cabozantinib

Cabometyx

Cometriq

n-(4- ((6, 7- dimethoxy -4- quinolinyl) oxy) fenil) -n '-(4- fluorophenyl) -1, 1-} cycloropan {{

1, 1- cyclopropanedicarboxamide, n '-(4- ((6, 7- dimethoxy -4- quinolinyl) oxy) fenil) -n-(4- fluorophen)-

1, 1- cyclopropanedicarboxamide, n-(4- ((6, 7- dimethoxy -4- quinolinyl) oxy) -n) --n '-({{

N-[4- [(6, 7- dimethoxy -4- quinolinyl) oxy] fenil] -n '-(4- fluorophenyl) -1, 1-} cycloropan {

N-{4- [(6, 7- dimethoxyquinolin -4- yl) oxy] fenil} -n '-(4- fluorophenyl) cyclopropane {8}}, {{{{

cabozantinibum

Cabozantinib; N '-? [4-? [(6,? 7-? Dimethoxy-? 4-? ? N-? (4-? Fluorophenyl)? -1 ,? 1- Cyclopropanedicarbox? N '-[4- [(6, 7- dimethoxy -4- quinolinyl) oxy] fenil] -n-(4- fluorophenyl) {{{ BMS 907351; N-[4- [(6, 7- dimethoxy -4- quinolinyl) oxy] fenil] -n '-(4- fluorophenyl) -1, 1-}} {

N-(4- ((6, 7- dimethoxyquinolin -4- yl) oxy) phenyl) -n '-(4- fluorophenyl) cyclopropane -1, {{{9}

Cabozantinib (estanda)

Cabozantinib (baz gratis)

 

 

 

 

Baj popilè: 849217-68-1 Cabozantinib, Lachin 849217-68-1 Konpayi fabrikasyon Cabozantinib, Swèd