515814-01-4 Voclosporin

Pwopriyete

Aparans blan nan koupe-blan solid
Pwen bouyi: 13 0 3.8 ± 65.0 degre
Dansite 1. 0 16 ± 0.06 g/cm3
Depo tanperati. Magazen nan -20 degre
Solubility benzèn (yon ti kras), methanol (yon ti kras)
PKA13.32 ± 0. 70
 

Aplikasyon:

Voclosporin se yon nouvo kalsyòm reglemante fosfataz inibitè, struktural ki sanble ak cyclosporine A. Apre modifikasyon, se aktivite li yo ogmante pa 3-4 fwa, epi li gen yon mekanis doub ak sinèrjetik. Pa anpeche kalsyòm reglemante fosfataz, li ka bloke ekspresyon an nan IL -2 ak T selil-medyatè repons iminitè, estabilize podosit ren. Konpare ak cyclosporine, vokyclosporine tou gen avantaj nan mwens enpak sou kolestewòl ak trigliserid, ak pi ba risk pou yo dyabèt.

 

Sinonim:

Voklosporin

515814-01-4

Luviq

Lupkynis

Voklosporin

voklosporina

R 1524

R-1524

(3s, 6s, 9s, 12r, 15s, 18s, 21s, 24s, 30s, 33s) -30- etil -33- [(1r, 2r, 4e) -1- hydroxy {{16} m ethylhepta -4, 6- dienyl] -1, 4,7,10,12,15,19,25, 28- nonamethyl -6, 9,18, {{3 3 1}} tetrakis (2- methylpropyl) -3, 21- di (propan -2- yl) -1, 4,7,10,13,16,19,2,2,2,2,2,19,19,19,2,2,19,19,19,2,2,19,19,19,2,2,19,19,19,19,2,2,19,19,2,2,19,19,19,2,2,19,19,19,2,2,2,19,19,19,19,2,2,2,19,19,2,2,2,19,19,19,2,2,2,2,19,19,19,2,2,2,2,19,19,2,2 2,25,28, 31- undecazacyclotritriacontane -2, 5,8,11,14,17,20,23,26,29, 32- Undecone

Voclosporin-D4

Cyclosporin A, 6- ((2s, 3r, 4r) -3- hydroxy -4- methyl -2- (methylamino) -6, 8- asid nonadienoic)-

(3s, 6s, 9s, 12r, 15s, 18s, 21s, 24s, 30s, 33s) -30- etil -33- ((1r, 2r, e) -1- hydroxy {{15 }} methylhepta -4, 6- dien -1- yl) -6, 9,18, 24- diisopropil -1, 4,7,10,12,15,19,25, 28- nonamethyl -1, 4,7,10,13,16,19,22,25, 28, 31- undecaazacyclotritriacontan -2, 5,8,11,14,17,20,23,26,29, 32- undecaone

Siklo (((E, z)-(2s, 3r, 4r) -3- Hydroxy -4- methyl -2- (methylamino) nona -6, 8- dienoyl) -l {{10} L-N-methyl-l-leucyl-l-valyl-n-methyl-l-leucyl-l-alanyl-d-alanyl-n-methyl-l-leucyl-n-methyl-l-leucyl-n-methyl-l-valyl)

voklosporinin

Lupkynis

1, 11- anhydro (l-alanyl-d-alanyl-n-methyl-l-leucyl-n-methyl-l-leucyl- N-methyl-l-valyl-((2s, 3r, 4r, 6e) -3- Hydroxy -4- methyl - 2- (methylamino) nona -6, 8-}} {{{ N-methylglycyl-n-methyl-l-leucyl-l-valyl-n-methyl-l-leucine)

Lx -214

Isatx -247; Luviq

6- [(2s, 3r, 4r, 6e) -3- Hydroxy -4- methyl -2- (methylamino) -6, {{9}

Voklosporin

Ex-A5922

AT27977

(3s, 6s, 9s, 12r, 15s, 18s, 21s, 24s, 30s, 33s) -30- etil -33- ((1r, 2r, e) -1- Hydrox y -2- methylhepta -4, 6- dien -1- yl) -6, 9,18, 24- Tetraisobutyl {{{ 23}}, 21- diisopropil -1, 4,7,10,12,15,19,25, 28- nonamethyl -1, 4,7,10 , 13,16,19,22,25,28, 31- undecaazacyclotritriacontan -2, 5,8,11,14,17,20,23

6- [(2s, 3r, 4r, 6e) -3- hydroxy -4- methyl -2- (methylamino) -6, {{9}

Cyclo (L-Alanyl-D-Alanyl-N-methyl-L-leucyl-n-methyl-l-leucyl-n-methyl-l-valyl- ) Aminobutanoyl-n-methylglycyl-n-methyl-l-leucyl-l-valyl-n-methyl-l-leucyl)

Cyclo (l-alanyl-d-alanyl-n-methyl-l-leucyl-n-methyl-l-leucyl-n-methyl-l-valyl-((2s, 3r, 4r, 6e) -3-} {

 

Baj popilè: 515814-01-4 Voclosporin, Lachin 515814-01-4 Voclosporin Manifaktirè, Swèd