1257044-40-8 Venetoclax

Pwopriyete

Aparans limyè jòn solid
Melting point:>150 degre (Dec.)
Dansite 1.34 0 ± 0.06 g/cm3
Depo tanperati. -20 degre frizè
Solubility DMSO (yon ti kras)
PKA4. 0 9 ± 0.10
 

Aplikasyon:

Venetoclax, ki te apwouve pa FDA a sou 11 avril 2016, se premye bcl nan mond lan -2 inibitè. Medikaman sa a se pa sèlman premye nan kalite li yo kòm yon BCL -2 inibitè pwoteyin, men tou, premye apwouve ti dwòg la molekil nan jaden an nan entèraksyon pwoteyin-pwoteyin, regilye nèf semenn klas yon etap enpòtan. Terapi konbinezon ak azacitidine pou pasyan egi lesemi myeloid ki gen laj 75 ak pi wo a.

Venetoclax gen yon vokasyon segondè pou domèn BH3 obligatwa nan Bcl -2, ki ka ankouraje apoptoz selil ak anpeche pwopagasyon selil pa anpeche ekspresyon an segondè nan Bcl -2 nan selil AML. Venetoclax ka itilize pou tretman an nan lesemi lenfosit kwonik, lesemi myeloid egi, ak myeloma miltip.

 

Sinonim:

Venetoclax

1257044-40-8

Abt -199

Venclexta

GDC -0199

Venclyxto

4- [4- [2- (4- chlorophenyl) -4, 4- dimet hylcyclohexen -1- yl] methyl] piperazin -1- yl] -n-[{{10} } nitro -4- (oxan -4- ylmethylamino) fenil] sulfonyl -2- (1H-pyrolo [2, 3- B] Pyridin -5- Yloxy) Benzame

Venetoclax (abt -199)

Abt -199 (GDC -0199)

Benzamid, 4- [4- [2- (4- chlorophenyl) -4, 4- dimethyl {{6 }} cyclohexen -1- yl] methyl] -1- piperazinyl] -n-[[3- nitr o -4- [[(tetrahydro -2 h-piran -4- yl) methyl] amino] fenil] sulfonyl] -2- (1H-pyrrolo [2, 3- b] b] b]}}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {}} {} {{

ABT 199 (Venetoclax)

2- (1H-Pyrrolo [2, 3- B] Pyridin -5- Yloxy) -4- ({ {7}} ((2- (4- chlorophenyl) -4, 4- dimethylc yclohex -1- enyl) methyl) piperazin -1- yl) -n-(3- nitro -4- ((tetrahydro -2 h-pyran {{20} y) {)

4- (4- ((2- (4- chlorophenyl) -4, 4- dimethylcycl Ohex -1- en -1- yl) methyl) piperazin -1- yl) -n-((3- nitro {{ 12}} ((tetrahydro -2 h-piran -4- ylmethyl) amino) fenil) sulfonyl) -2- (1H-pirrolo (2, 3- b) pyridin {{{{

4- (4- {[2- (4- chlorophenyl) -4, 4- dimethyl cyclohex -1- en -1- yl] methyl} piperazin -1- yl) -n-({{{11 }} nitro -4- [(oxan -4- ylmethyl) amino] benzèn} sulfonyl) -2- {1H-pyrrolo [2, 3- b] piridin -5-}} {}}}

 

Baj popilè: 1257044-40-8 Venetoclax, Lachin 1257044-40-8 manifaktirè Venetoclax, Swèd