1197953-54-0 Brigatinib

Pwopriyete
Melting point:>203 degre (Dec.)
Pwen bouyi: 781.8 ± 7 0. 0 degre
Dansite 1.31 ± 0. 1 g/cm3
Depo tanperati. -20 degre
solubility soluble nan DMSO (1 mg/ml ak planèt la)
PKA8.14 ± 0. 42
Aparans blan nan koupe-blan solid

 

Aplikasyon:

Brigatinib inibit kwasans lan ak gaye nan selil kansè nan pa bloke fonksyon an nan proteasomes.

Proteasome se youn nan sistèm degradasyon pwoteyin enpòtan nan selil yo, ki enplike nan reglemante aktivite lavi selilè. Brigatinib ka entèfere ak metabolis la ak pwopagasyon nan selil kansè nan pa espesyalman obligatwa ak ak anpeche anzim proteasome, pwomosyon selil kansè nan antre nan yon eta apoptotic.

Brigatinib se sitou administre atravè piki nan venn ak se souvan itilize pou tretman an nan myelom miltip, espesyalman nan ka avanse ak REFRACTORY. Li se tou itilize nan trete sèten lòt kalite lesemi ak ki pa Hodgkin lenfom.

 

Sinonim:

Brigatinib

1197953-54-0

AP 26113

(2- ((5- chloro -2- ((2- methoxy -4- (4- (4- methylpiperazin -1-} yl yl yl { ) piperidin -1- yl) fenil) amino) pirimidin -4- yl) amino) fenil) dimethylphosphine oksid

5- chloro -4- n-(2- dimethylphosphorylphenyl) -2- n-[2- methoxy -4- [4- ({{{ {9}} methylpiperazin -1- yl) piperidin -1- yl] fenil] pirimidine -2, 4- Diamine

2, 4- Pyrimidinediamine, 5- chloro-n 4- (2- (dimethylphosphinyl) fenil) -n 2- (2- methox y -4- (4- (4- methyl -1- Piperazinyl) -1- Piperidinyl) fenil)-

(2- ((5- chloro -2- ((2- methoxy -4- (4- (4- methylpiperazin -1- yl) pip) { nan -1- yl) fenil) amino) pirimidin -4- yl) amino) fenil) dimethyl-, delta 5- fosfanòn

5- chloro-n ~ 4 ~-[2- (dimethylphosphoryl) fenil] -n ~ 2 ~-{2- metoksi -4- [4- ({{{ {11}} methylpiperazin -1- yl) piperidin -1- yl] fenil} pirimidine -2, 4- Diamine

5- chloro-n 4- (2- (dimethylphosphoryl) fenil) -n 2- (2- Methoxy -4- (4-} ( 4- methylpiperazin -1- yl) piperidin -1- yl) fenil) pyrimidine -2, 4- Diamine

brigatinib

Alunbrig

5- chloro-n 4- [2- (dimethylphosphinyl) fenil] -n 2- [2- {-4- {9}} methyl -1- piperazinyl) -1- piperidinyl] fenil] -2, 4- Pyrimidinediamine; AP 26113

Brigatinib; AP26113

Brigatinib (ap -26113)

(2- ((5- chloro -2- ((2- methoxy -4- (4- (4- methylpiperazin -1-}}}} yl) { N -1- yl) fenil) amino) pirimidin -4- yl) amino) fenil) dimethyl-,. Delta. 5- phosphanone

(2- ((5- chloro -2- (2- methoxy -4- (4- (4- methylpiperazin -1- yl) piperazin {7}} yl) {} { idin -1- yl) anilino) pirimidin -4- yl) amino) fenil) dimethyl-lambda 5- phosphanone

2- ((5- chloro -2- ((2- methoxy -4- (4- (4- methylpiperazin -1- yl) yl)}}}} { piperidin -1- yl) fenil) amino) pirimidin -4- yl) amino) fenil) dimethylphosphine bèf ide

5- chloro-n 4- (2- (dimethylphosphoryl) fenil) -n 2- (2- Methoxy -4 (4-} ( 4- methylpiperazin -1- yl) piperidin -1- yl) fenil) pyrimidine -2, 4- Diamine

 

 

 

Baj popilè: 1197953-54-0 Brigatinib, Lachin 1197953-54-0 Brigatinib Konpayi fabrikasyon, Swèd